How Might Consideration of Cell Polarity Affect Daily Therapeutic Practices? A Literature Review

Background: In addition to biochemical gradients and transcriptional networks, cell behaviour is controlled by endogenous bioelectrical signals resulting from the action of ion channels pumps. Cells are regulated not only their own membrane resting potential (Vmem) but also Vmem neighbouring cells, establishing networks through electrical synapses known as gap junctions. V mem primary factor in producing a polarity that can regulate assimilation various substances. This article aimed examine how change variations may lead clinical demonstrations.Materials Methods: Using Cochrane Central, PubMed, Scopus, Web Science (WOS), Embase, comprehensive qualitative literature review was conducted February 1, 2018, 2023, identify studies addressing bioelectric, polarity, electroceuticals patients with foot ankle problems.Results: Out 1,281 publications, 27 were included. One study investigated bioelectric wound-healing. Twenty-five examined nerve growth, whereas one evaluated bioelectricity-induced cellular differentiation treatment arteriopathies.Conclusion: The author this systematic support predisposing factors healing impediments for disease, thereby enhancing process reducing likelihood recurrence or parallel conditions. method has provided summary evidence indicating could be addressed prevention most if all, problems. However, owing limitations bioelectricity measurement direct indirect involvement genetics chemical gradients, further required confirm these results.